Events
Past Event
WED@NICO SEMINAR: Natalia Komarova, University of California, Irvine "Stochastic calculus of stem cells"
Northwestern Institute on Complex Systems (NICO)
12:00 PM
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Lower Level Chambers Hall
Details
Title:
Stochastic calculus of stem cells
Speaker:
Natalia Komarova - Professor, Department of Mathematics, University of California, Irvine
Talk Abstract:
Stem cells are an important component of tissue architecture. Identifying the exact regulatory circuits that can stably maintain tissue homeostasis (that is, approximately constant size) is critical for our basic understanding of multicellular organisms. It is equally critical for figuring out how tumors circumvent this regulation, thus providing targets for treatment. Despite great strides in the understanding of the molecular components of stem-cell regulation, the overall mechanisms orchestrating tissue homeostasis are still far from being understood. Typically, tissue contains the stem cells, transit amplifying cells, and terminally differentiated cells. Each of these cell types can potentially secrete regulatory factors and/or respond to factors secreted by other types. The feedback can be positive or negative in nature. This gives rise to a bewildering array of possible mechanisms that drive tissue regulation. In this talk I describe a novel stochastic method of studying stem cell lineage regulation, which is based on population dynamics and ecological approaches. The method allows to identify possible numbers, types, and directions of control loops that are compatible with stability, keep the variance low, and possess a certain degree of robustness. I will also discuss evolutionary optimization and cancer-delaying role of stem cells.
Live Stream:
To join the Meeting: bluejeans.com/8474912527
To join via Browser: bluejeans.com/8474912527/browser
Time
Wednesday, May 3, 2017 at 12:00 PM - 1:00 PM
Location
Lower Level Chambers Hall Map
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Northwestern Institute on Complex Systems (NICO)
No classes - Memorial Day - University offices are closed
University Academic Calendar
All Day
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No classes - Memorial Day - University offices are closed
Time
Monday, May 25, 2026
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Data Science Nights - MAY 2026 - Speaker: Xudong Tang, Computer Science and NICO
Northwestern Institute on Complex Systems (NICO)
5:30 PM
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M416, Technological Institute
Details
MAY MEETING: Thursday, May 28, 2026 at 5:30pm (US Central)
LOCATION:
ESAM Conference Room, Tech M416
2145 Sheridan Road, Evanston, IL 60208
AGENDA:
5:30pm - Meet and greet with refreshments
6:00pm - Talk with Xudong Tang, PhD Student, Computer Science, NICO, and the Human-AI Collaboration Lab, Northwestern University
TALK TITLE:
Human and Machine Perception of Voice Similarity
ABSTRACT:
Modern voice cloning systems generate synthetic speech that listeners frequently cannot identify as being synthetic. But a voice can sound natural without sounding like the intended person, and what determines whether a clone is heard as a particular person is an open question. Here we report a large-scale preregistered experiment in which we collected 92,239 responses from 175 participants on their perception of pairs of real recordings, voice clones, and continuously morphed voices drawn from 100 contemporary celebrities across 20 speaker groups. We find that voice clones do not reliably preserve perceived speaker identity, reducing same-speaker judgments by 12.7 percentage points even though the clones are produced by a state-of-the-art text-to-speech model, while leaving different-speaker judgments unchanged. Using continuously morphed stimuli, we find that speakers vary substantially in how much variation their perceived identity tolerates, and that this variation is not predicted by speaker demographics. Speaker embeddings account for 58.9\% (95\% CI = [55.7, 61.9]) of variance in identity judgments, which is more than acoustic features, social attributes, and clone status combined. Once all these observed features are accounted for, clone status adds no additional predictive power. These results shows that the perceptual impact of voice cloning is positional rather than categorical: we can model how listeners judge a voice by how close it falls to the perceptual boundary that defines each speaker's recognizable voice, applying the same criterion to real and synthetic speech alike.
DATA SCIENCE NIGHTS are monthly meetings featuring presentations and discussions about data-driven science and complex systems, organized by Northwestern University graduate students and scholars. Students and researchers of all levels are welcome! For more information: http://bit.ly/nico-dsn
FUTURE DATES:
Data Science Nights will return in September!
Time
Thursday, May 28, 2026 at 5:30 PM - 7:00 PM
Location
M416, Technological Institute Map
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Calendar
Northwestern Institute on Complex Systems (NICO)
Spring 2026 Commencement
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Spring 2026 Commencement
Time
Sunday, June 14, 2026
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Juneteenth - University Closed
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Juneteenth - University Closed
Time
Friday, June 19, 2026
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Independence Day (observed) - University Closed
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Independence Day (observed) - University Closed
Time
Friday, July 3, 2026
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Fall 2026 Classes Begin
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Fall 2026 Classes Begin
Time
Wednesday, September 23, 2026
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