Computational Analysis of Dynamic of T Cell Signaling to Elucidate Immune Function

Neda Bagheri 

Wednesdays@NICO Seminar, Noon, February 15 2012, Chambers Hall, Lower Level

Prof. Neda Bagheri, Northwestern University

Abstract

Effective immune responses rely on the recognition of and response to antigens through precise dynamic coordination of cytokines secreted by activated T cells. Through serial microengraving [1], the Love Lab is able to quantify single T cell cytokine secretion, offering a unique multidimensional perspective to study time-dependent functional differences specific to immunophenotypes. We employ computational strategies derived from control theory to these data to investigate the temporal and multifunctional kinetics of specific cytokine responses that are indicative of a healthy response. Resolving the regulatory networks that govern T cell responses should enable the identification of productive time-dependent cytokine signatures, offering insight toward more effective, personalized treatment strategies.

Biography

Bagheri completed her studies at the University of California Santa Barbara in electrical engineering. Her graduate research, conducted with Professor Frank Doyle, combined control theory with biological measurements to investigate circadian regulation, structure, and robust phase dynamics. After completing her PhD, Bagheri conducted postdoctoral research with Professor Doug Lauffenburger at MIT’s Department of Biological Engineering, where she integrated computational and experimental studies to investigate cell regulatory dynamics underlying virus-host interaction and immune function. Bagheri’s research objective is to employ control theory principles to address modern challenges in medicine and biology. Additional Information can be found on her website http://bagheri.northwestern.edu/people.html